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Nursing mothers: Caution ought to be exercised each time a barbiturate is administered to a nursing female since smaller amounts of barbiturates are excreted in the milk.pentobarbital decreases levels of vandetanib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Stay clear of coadministration with potent CYP3A4 inducers;

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Barbiturates are absorbed in varying levels adhering to oral, rectal, or parenteral administration. The salts tend to be more swiftly absorbed than tend to be the acids.pentobarbital decreases amounts of vandetanib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Keep away from coadministration with strong CYP3A4 inducers;

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